THE 2-MINUTE RULE FOR BET ON SPORTS

DNA ligases seal 5′-PO4 and 3′-OH polynucleotide ends by means of a few nucleotidyl transfer steps involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are critical guardians of genomic integrity, and ligase dysfunction underlies human genetic disorder syndromes. Crystal constructions of DNA ligases sure to nucleotide and nuc